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1

Epidermal growth factor receptor mutations in lung cancer

Sharma, Sreenath V., Bell, Daphne W., Settleman, Jeffrey, Haber, Daniel A.

Journal:

Nature Reviews Cancer

Year:

2007

Language:

english

File:

PDF, 441 KB

english, 2007

2

A Structure-Guided Approach to Creating Covalent FGFR Inhibitors

Wenjun Zhou, Wooyoung Hur, Ultan McDermott, Amit Dutt, Wa Xian, Scott B. Ficarro, Jianming Zhang, Sreenath V. Sharma, Joan Brugge, Matthew Meyerson, Jeffrey Settleman, Nathanael S. Gray

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

3

GAP control: regulating the regulators of small GTPases

Andre Bernards, Jeffrey Settleman

Journal:

Trends in Cell Biology

Year:

2004

Language:

english

File:

PDF, 463 KB

english, 2004

4

p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho

Gregg A. Wildenberg, Michael R. Dohn, Robert H. Carnahan, Michael A. Davis, Nichole A. Lobdell, Jeffrey Settleman, Albert B. Reynolds

Journal:

Year:

2006

Language:

english

File:

PDF, 2.03 MB

english, 2006

5

The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

Kathy Barrett, Maria Leptin, Jeffrey Settleman

Journal:

Year:

1997

Language:

english

File:

PDF, 706 KB

english, 1997

6

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis

David J. Riese II, Richard M. Gallo, Jeffrey Settleman

Journal:

Year:

2007

Language:

english

File:

PDF, 157 KB

english, 2007

7

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

Dora Dias-Santagata, Sara Akhavanfard, Serena S. David, Kathy Vernovsky, Georgiana Kuhlmann, Susan L. Boisvert, Hannah Stubbs, Ultan McDermott, Jeffrey Settleman, Eunice L. Kwak, Jeffrey W. Clark, Ste

Journal:

EMBO Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 790 KB

english, 2010

8

Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy

Luni Emdad, Irina V. Lebedeva, Zao-Zhong Su, Pankaj Gupta, Devanand Sarkar, Jeffrey Settleman, Paul B. Fisher

Journal:

Journal of Cellular Physiology

Year:

2007

Language:

english

File:

PDF, 497 KB

english, 2007

9

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva

Pankaj Gupta, Luni Emdad, Irina V. Lebedeva, Devanand Sarkar, Paul Dent, David T. Curiel, Jeffrey Settleman, Paul B. Fisher

Journal:

Journal of Cellular Physiology

Year:

2008

Language:

english

File:

PDF, 351 KB

english, 2008

10

Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

Chan-Young Jeon, Hee-Jun Kim, Hiroshi Morii, Nozomu Mori, Jeffrey Settleman, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park

Journal:

Journal of Cellular Physiology

Year:

2010

Language:

english

File:

PDF, 315 KB

english, 2010

11

Erratum: Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

Chan-Young Jeon, Hee-Jun Kim, Hiroshi Morii, Nozomu Mori, Jeffrey Settleman, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park

Journal:

Journal of Cellular Physiology

Year:

2011

Language:

english

File:

PDF, 43 KB

english, 2011

12

Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase duringDrosophiladevelopment

Valerie Verdier, Guang-Chao-Chen, Jeffrey Settleman

Journal:

BMC Developmental Biology

Year:

2006

Language:

english

File:

PDF, 1.47 MB

english, 2006

13

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

Brouns, Madeleine R., Matheson, Stephen F., Settleman, Jeffrey

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 1.00 MB

english, 2001

14

Association between GTPase activators for Rho and Ras families

Settleman, Jeffrey, Albright, Charles F., Foster, Lauren C., Weinberg, Robert A.

Journal:

Year:

1992

File:

PDF, 250 KB

1992

15

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

Zhang, Xian-Feng, Settleman, Jeffrey, Kyriakis, John, Takeuchi-Suzuki, Erika, Elledge, Stephen J., Marshall, Mark S., Bruder, Joseph T., Rapp, Ulf R., Avruch, Joseph

Journal:

Year:

1993

File:

PDF, 758 KB

1993

16

10.1038/71390

Settleman, Jeffrey

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 123 KB

english, 2000

17

E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells

Maheswaran, Shyamala, Englert, Christoph, Lee, Sean Bong, Ezzel, Robert M, Settleman, Jeffrey, Haber, Daniel A

Journal:

Year:

1998

Language:

english

File:

PDF, 1.20 MB

english, 1998

18

RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion

Zrihan-Licht, Sheila, Fu, Yigong, Settleman, Jeffrey, Schinkmann, Karin, Shaw, Leslie, Keydar, Iafa, Avraham, Shalom, Avraham, Hava

Journal:

Year:

2000

Language:

english

File:

PDF, 495 KB

english, 2000

19

Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins

Adrian Partow, Roger A. Grand, Paul Biggs, Settleman Jeffrey, Daniel Dimaio, Phillip H. Gallimore

Journal:

Year:

1990

Language:

english

File:

PDF, 2.40 MB

english, 1990

20

The complexity of targeting EGFR signalling in cancer: From expression to turnover

Sinto Sebastian, Jeffrey Settleman, Stephan J. Reshkin, Amalia Azzariti, Antonia Bellizzi, Angelo Paradiso

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2006

Language:

english

File:

PDF, 654 KB

english, 2006

21

Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance

Csilla Hegedüs, Krisztina Truta-Feles, Géza Antalffy, György Várady, Katalin Német, Csilla Özvegy-Laczka, György Kéri, László Őrfi, Gergely Szakács, Jeffrey Settleman, András Váradi, Balázs Sarkadi

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 905 KB

english, 2012

22

A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes

Sreenath V. Sharma, Patrycja Gajowniczek, Inna P. Way, Diana Y. Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey Settleman

Journal:

Year:

2006

Language:

english

File:

PDF, 1.43 MB

english, 2006

23

Drugging the Bad “AKT-TOR” to Overcome TKI-Resistant Lung Cancer

Jeffrey Settleman, Jonathan M. Kurie

Journal:

Year:

2007

Language:

english

File:

PDF, 78 KB

english, 2007

24

A Common Signaling Cascade May Underlie “Addiction” to the Src, BCR-ABL, and EGF Receptor Oncogenes

Sreenath V. Sharma, Patrycja Gajowniczek, Inna Way, Diana Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey Settleman

Journal:

Year:

2009

File:

PDF, 256 KB

2009

25

Rho-LIM Kinase Signaling Regulates Ecdysone-Induced Gene Expression and Morphogenesis during Drosophila Metamorphosis

Guang-Chao Chen, Patrycja Gajowniczek, Jeffrey Settleman

Journal:

Current Biology

Year:

2004

Language:

english

File:

PDF, 537 KB

english, 2004

26

Adhesion-Dependent Regulation of p190RhoGAP in the Developing Brain by the Abl-Related Gene Tyrosine Kinase

Samuel E Hernández, Jeffrey Settleman, Anthony J Koleske

Journal:

Current Biology

Year:

2004

Language:

english

File:

PDF, 425 KB

english, 2004

27

The Drosophila ATM Ortholog, dATM, Mediates the Response to Ionizing Radiation and to Spontaneous DNA Damage during Development

Young-Han Song, Gladys Mirey, Martha Betson, Daniel A Haber, Jeffrey Settleman

Journal:

Current Biology

Year:

2004

Language:

english

File:

PDF, 404 KB

english, 2004

28

Coordination of Rho and Rac GTPase Function via p190B RhoGAP

Rodrigo I. Bustos, Marie-Annick Forget, Jeffrey E. Settleman, Steen H. Hansen

Journal:

Current Biology

Year:

2008

Language:

english

File:

PDF, 478 KB

english, 2008

29

Oncogene addiction

Jeffrey Settleman

Journal:

Current Biology

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

30

ErbBs in lung cancer

Sreenath V. Sharma, Jeffrey Settleman

Journal:

Experimental Cell Research

Year:

2009

Language:

english

File:

PDF, 984 KB

english, 2009

31

Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization

Sylvie Vincent, Jeffrey Settleman

Journal:

European Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 3.29 MB

english, 1999

32

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

Krister Wennerberg, Marie-Annick Forget, Shawn M Ellerbroek, William T Arthur, Keith Burridge, Jeffrey Settleman, Channing J Der, Steen H Hansen

Journal:

Current Biology

Year:

2003

Language:

english

File:

PDF, 576 KB

english, 2003

33

The Role of Rho Family GTPases in Development: Lessons from Drosophila melanogaster

Yu Lu, Jeffrey Settleman

Journal:

Molecular Cell Biology Research Communications

Year:

1999

Language:

english

File:

PDF, 174 KB

english, 1999

34

Intercalating Arabidopsis Leaf Cells: A Jigsaw Puzzle of Lobes, Necks, ROPs, and RICs

Jeffrey Settleman

Journal:

Year:

2005

Language:

english

File:

PDF, 139 KB

english, 2005

35

PAK-in' Up cGMP for the Move

Jeffrey Settleman

Journal:

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

36

Acquired resistance to tyrosine kinase inhibitors during cancer therapy

Jeffrey A Engelman, Jeffrey Settleman

Journal:

Current Opinion in Genetics & Development

Year:

2008

Language:

english

File:

PDF, 170 KB

english, 2008

37

An FF Domain-Dependent Protein Interaction Mediates a Signaling Pathway for Growth Factor-Induced Gene Expression

Wei Jiang, Raffaella Sordella, Guang-Chao Chen, Shweta Hakre, Ananda L. Roy, Jeffrey Settleman

Journal:

Year:

2005

Language:

english

File:

PDF, 800 KB

english, 2005

38

Opposing Functions of TFII-I Spliced Isoforms in Growth Factor-Induced Gene Expression

Shweta Hakre, María Isabel Tussie-Luna, Todd Ashworth, Carl D. Novina, Jeffrey Settleman, Phillip A. Sharp, Ananda L. Roy

Journal:

Year:

2006

Language:

english

File:

PDF, 501 KB

english, 2006

39

Editorial

Jeffrey Settleman, Buzz Baum

Journal:

Seminars in Cell & Developmental Biology

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

40

Transitions between epithelial and mesenchymal states in development and disease

Buzz Baum, Jeffrey Settleman, Margaret P. Quinlan

Journal:

Seminars in Cell & Developmental Biology

Year:

2008

Language:

english

File:

PDF, 802 KB

english, 2008

41

Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

Valerie Verdier, James E. Johndrow, Martha Betson, Guang-Chao Chen, David A. Hughes, Susan M. Parkhurst, Jeffrey Settleman

Journal:

Developmental Biology

Year:

2006

Language:

english

File:

PDF, 1.03 MB

english, 2006

42

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

Brandy M. Heckman, Geetika Chakravarty, Tracy Vargo-Gogola, Maria Gonzales-Rimbau, Darryl L. Hadsell, Adrian V. Lee, Jeffrey Settleman, Jeffrey M. Rosen

Journal:

Developmental Biology

Year:

2007

Language:

english

File:

PDF, 3.76 MB

english, 2007

43

Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity

Thomas H Barker, Hernan E Grenett, Mark W MacEwen, Samuel G Tilden, Gerald M Fuller, Jeffrey Settleman, Anne Woods, Joanne Murphy-Ullrich, James S Hagood

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 592 KB

english, 2004

44

Erratum

Raffaella Sordella, Wei Jiang, Guang-Chao Chen, Marcello Curto, Jeffrey Settleman

Journal:

Year:

2003

File:

PDF, 58 KB

2003

45

Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

Raffaella Sordella, Wei Jiang, Guang-Chao Chen, Marcello Curto, Jeffrey Settleman

Journal:

Year:

2003

Language:

english

File:

PDF, 645 KB

english, 2003

46

A memory GAP

Jeffrey Settleman

Journal:

Trends in Neurosciences

Year:

2003

Language:

english

File:

PDF, 75 KB

english, 2003

47

A Nuclear MAL-Function Links Rho to SRF

Jeffrey Settleman

Journal:

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

48

Tension Precedes Commitment—Even for a Stem Cell

Jeffrey Settleman

Journal:

Year:

2004

Language:

english

File:

PDF, 79 KB

english, 2004

49

Rac 'n Rho: The Music that Shapes a Developing Embryo

Jeffrey Settleman

Journal:

Developmental Cell

Year:

2001

Language:

english

File:

PDF, 460 KB

english, 2001

50

Modulation of CREB Activity by the Rho GTPase Regulates Cell and Organism Size during Mouse Embryonic Development

Raffaella Sordella, Marie Classon, Kang-Quan Hu, Stephen F. Matheson, Madeleine R. Brouns, Barry Fine, Le Zhang, Hiroya Takami, Yoshihiko Yamada, Jeffrey Settleman

Journal:

Developmental Cell

Year:

2002

Language:

english

File:

PDF, 669 KB

english, 2002

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